Methemoglobin Formation and Characterization of Hemoglobin Adducts of Carcinogenic Aromatic Amines and Heterocyclic Aromatic Amines
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چکیده
منابع مشابه
Heterocyclic Aromatic Amines Formation in Grilled Fatty Fish
The consumption of fish provides utilization of proteins of high biological value, certain minerals, and vitamins. Additionally, fish and fish oil are rich sources of omega-3 fatty acids. Sardine (Sardina pilchardus) and salmon (Salmo salar) are fish species rich in omega-3 PUFAs. On the other hand, fish is usually cooked in different ways before consumption and heat treatment can lead to undes...
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N-Hydroxylation and mutagenic activation of heterocyclic aromatic amines from protein pyrolysis products were studied in rat liver microsomes and nuclei, rat hepatocytes and various species of purified cytochrome P-450. These mutagenic amines include Trp-P-2 (3-amino-1-methyl-5H-pyrido[4,3-b]indole), Trp-P-1 (3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole), Glu-P-1 (2-amino-6-methyldipyrido-[1,2-a...
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The N-hydroxylation of carcinogenic arylamines represents an initial step in their metabolic activation. Animal studies have shown that this reaction is catalyzed by the cytochrome P450 (P450) enzymes P450 1A1 and P450 1A2. In this study, utilizing enzymes expressed in Escherichia coli (and purified) or in human B-lymphoblastoid cells, the catalytic activities of recombinant human P450 1A1, P45...
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A new method for the simultaneous determination of hemoglobin adducts from aromatic amines and tobacco-specific nitrosamines (TSNA) is described. After mild base-catalysed hydrolysis releasing aromatic amines and the TSNA adduct 4-hydroxy-1-(3-pyridyl)-1butanone (HPB), the extraction, cleanup, and concentration are performed by a one-step procedure using C 1 8 cartridges. Determination in the p...
متن کاملHemoglobin adducts of aromatic amines: associations with smoking status and type of tobacco.
Hemoglobin adducts of 15 aromatic amines were determined in nonsmokers and smokers of blond- or black-tobacco cigarettes living in Turin, Italy. The subjects were all males age 55 or less and were representative of the population previously examined in a case/control study of bladder cancer. 4-Aminobiphenyl adduct levels were found to be significantly different in the three groups, and the diff...
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ژورنال
عنوان ژورنال: Chemical Research in Toxicology
سال: 2016
ISSN: 0893-228X,1520-5010
DOI: 10.1021/acs.chemrestox.5b00418